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9 Several preexisting diseases, particularly cardiopulmonary diseases (such as pulmonary hypertension and bleeding disorders), may increase susceptibility to high-altitude disease

Yoon, E., Babar, A., Choudhary, M., Kutner, M

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Evidence Limitations No human RCTs

The present study also explores the possibility that the oxidized inactive form of e-GST may be present in blood, given that two critical cysteines, Cys47 and Cys101 (the latter corresponding to Cys103 in pig e-GST) are strictly conserved in all mammals tested, and that they form a disulfide both in vivo and in vitro as proved for the human enzyme

Study Population The study enrolled adult participants diagnosed with migraine with aura based on the criteria outlined in the International Classification of Headache Disorders, 3rd edition (ICHD-3) [12]