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The structurally simplified Ang IV peptidemimetic 16 was almost as active as Ang IV as an IRAP inhibitor while 17 was five-fold and 18 and the open chain 19 were 20-fold less active (Figure 5)

There was a possibly significant decrease in serine, changing from slightly above the average neurotypical value to slightly below

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These antibodies do not stain frozen or paraffin sections of normal human and mouse tissues