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A broad number of studies have demonstrated the reduction of glucose uptake in the brain of AD patients, and, in agreement, positron emission tomography (PET) scanning shows a consistent reduction of cerebral glucose consumption in the brain of AD patients (390, 391)

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doi: 10.1016/j.mam.2004.03.001

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Rapid regulation is especially important to the C-subfamily of ABC transporters (ABCC family), which includes Ycf1 and CFTR, in particular because of their roles in regulating osmotic balance, neutralizing reactive oxygen species, or combating the effects of antifungal or anticancer agents in many organisms

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However, pre-clinical data will help improve patient selection for future clinical trials, assess restoration of brain connectivity, and monitor inflammatory processes in the continuous search of novel therapeutic targets (Politis and Piccini, 2010)

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Among these modified proteins, we found DLD with a modification at Cys 477 , together with multiple proteins (31 out of 149, ~20%) belonging to components of the known interactome of DLD (Fig

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