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In-Vitro Pharmacology and Selectivity Biochemical profiling places 5-Amino-1MQ potency for research NNMT in the low-micromolar IC range under standardized assay conditions, with cell-based EC values in the low micromolar range for lowering 1-MNA and suppressing lipogenesis

The inclusion criteria consisted of original research articles, clinical trials, and systematic reviews published in peer-reviewed journals during the designated period

Future work should prioritize delivery platforms that localize exposure to pelvic lesions, including intraperitoneal or intralesional depots and nanocarriers, alongside triggerable or receptor-guided prodrugs designed to activate within the biochemical milieu of lesions

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Lu et al., 2022

Research outcomes should not be extrapolated to expected human results