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However, other studies have shown that TGF-1, through Smad3 activation, inhibits the expression of the glutamate-cystine antiporter system Xc-, enhancing lipid peroxidation levels in PLC/PRF/5, Huh7, Huh6, and Hep G2 cells marked by early TGF-1 genes, but not in cells marked by late TGF-1 genes [122]

Table 2 Oncogenes and tumor suppressor genes regulate tumor Gln metabolism

[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Ventriglio A., Bellomo A., Donato F., Iris B., Giovanna V., Dario D.S., Edwige C., Pettorruso M., Perna G., Valchera A., De Berardis D

doi: 10.1186/s13075-020-02349-y 60 ZhangRMiaoJZhangKZhangBLuoXSunHet al

Nanoparticle-based drug delivery for therapy of lung cancer: progress and challenges
