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Their catalytic efficiency is far greater than that of non-biological catalysts, enabling them to facilitate more than 5,000 biochemical reactions, including transcription, translation, protein synthesis, redox reactions for energy production, antibiotic biosynthesis, immune response, and many others ( 2.1.1 Isocitrate dehydrogenase (IDH1/2) Among metabolic enzymes, isocitrate dehydrogenases (IDHs) are particularly important

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