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It was initially thought that the presence of a particular histidine residue at the 63rd position with a pK a of around 6.4 probably serves a critical role in mediating this pH dependent switch of the protein

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found that circ_0001093 can competitively bind to miR-579-3p, leading to the upregulation of GLS, which stimulates Gln metabolism and the malignant progression of esophageal squamous cell carcinoma (ESCC) (59)

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The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression

Nat Rev Cancer 16(11):749
