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ICH Guideline Q3C (R5) on Impurities: Guideline for Residual Solvents (2011)

DISCUSSION In the present study, we found that in human testes FOXO4 was specifically expressed in Leydig cells, that FOXO4 showed nuclear translocation in Leydig cells within old testes, and that the nuclear translocation of FOX04 was related to decreased testosterone synthesis

Frequency recommendations vary by injury severity

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