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27 - A9, B2, Page 444 and 445: Feb
These defects occur between the 21 st and 28 th days after conception, a time when many women do not realize that they are pregnant (58)
Williamson, S
Importantly, all cis- and trans- regulatory elements mostly exert their effects not only on the apoC1 gene alone but on the whole ApoE/C1/C1/C2/C4 gene cluster [23, 24, 26,27,28]
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Deficiency develops gradually, as the body stores approximately 2-5 mg of B12 in the liver, which can sustain normal function for several years even with inadequate intake or absorption
