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Heres why: Vitamins B1, B2, B3 (Thiamine, Riboflavin, Niacin) Needed for energy production Help the body process carbohydrates, fats and proteins Support the nervous system and mitochondrial function Niacinamide (a form of B3) is also used topically for acne due to its anti-inflammatory benefits Symptoms of deficiencies may include: Fatigue Cracked corners of the lips Inflammation of the tongue (glossitis) Skin problems like dermatitis Note: High doses of certain forms of niacin can trigger flushing, which may feel like its worsening skin conditions like rosacea

[DOI] [PubMed] [Google Scholar] 45.Li J

Kocinaj A, Chaudhury T, Uddin MS, Junaid RR, Ramsden DB, Hondhamuni G, Klamt F, Parsons L, Parsons RB (2021) High Expression of nicotinamide N -Methyltransferase in patients with sporadic alzheimers disease

WADA category S5 is made up predominantly of diurectics including furosemide, hydrochlorothiazide, spironolactone, and acetazolamide