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Although not an inclusion or exclusion criteria, use of SGLT2i was implemented to stratify patients as they were randomized in the trial

2019;29:320334.e5

While there are limitations, the promise of improved diabetes management, cardiovascular benefits, and new formulations places GLP-1 agonists at the forefront of diabetes care

So adding tirzepatide on top does not introduce a new mechanism, it mainly adds side effects

Semaglutide stays in your system for several days, continuing to reduce appetite and stabilize blood sugar at a lower level than before treatment

By supporting healthy glucose levels, this approach not only stabilizes energy levels throughout the day but also plays a significant role in preventing the sharp insulin spikes that can lead to fatigue and irritability