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doi: 10.3748/wjg.v21.i9.2759 133 HughesDJFedirkoVJenabMSchomburgLMplanCFreislingHet al

Cuprizone intake also results in BBB breakdown and a limited infiltration of peripheral immune cells
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They prevent excessive immune activation and suppress autoreactive T cells that would otherwise attack the body own tissues

Controlled long-term data comparing tolerance development between the two compounds does not yet exist

Additionally, lower responses to anti-CD38 antibodies have been associated with low CD38 expression
