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Some people experience unpleasant side effects (e.g., nausea, constipation) that do not resolve over time, preventing its continued use

Cost-Effectiveness Analysis: Cost per Pound Lost (Estimated): Oral Semaglutide (Rybelsus): Average weight loss: 10 pounds (for 250 lb person) Cost: $900-$1,000/month for 6 months = $5,400-$6,000 Cost per pound lost: $540-$600 Injectable Semaglutide (Compounded from TrimRx): Average weight loss: 37 pounds (for 250 lb person) Cost: $199/month for 16 months = $3,184 Cost per pound lost: $86 Injectable Tirzepatide (Compounded from TrimRx): Average weight loss: 56 pounds (for 250 lb person) Cost: $349/month for 18 months = $6,282 Cost per pound lost: $112 Value Comparison: Hidden Costs: Oral Semaglutide: No injection supplies needed (saves $20-30/month) May require acid reflux medication if SNAC causes irritation Potential need for additional weight loss interventions if not effective Injectable Medications: Injection supplies usually included or inexpensive Sharps container ($5-10 one-time) Potential anti-nausea medication ($10-30/month if needed) Insurance Variables: If your insurance covers Rybelsus with a $25-$50 copay, it may seem like an attractive option

Dont be fearful, but if you recently started having night sweats your doctor needs to know about it, Ojile says

Brault, a health psychologist, specializes in behavioral weight management and lifestyle change

Metformin received FDA approval in 1994 for type 2 diabetes and with its beneficial effect on glycated hemoglobin (HbA1c), efficacy, and safety being wellestablished, 3 , 4 , 5 it became the recommended firstline choice for patients with type 2 diabetes in 2005