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Nat Commun 16 , 6343 (2025)

The rapid delivery restores electrolyte balance and supports brain and muscle function

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In hypertension, it may be that low NO levels result in reduced expression of CSE with a subsequent decrease in H 2 S production, lowering plasma concentrations and increasing vascular contraction

This is likely to be a driving force that provided the impetus for the ancestral protein to evolve in a manner that weaken its binding affinity for electrophilic compounds by mutating residues 100, 104 and 108 and that interferes with the formation of the intermediate complex by mutating residue 101

This, together with the observed normoglycemia and normal Hb1Ac levels, shows that A-KO Hoip mice are not diabetic but show a prediabetic signature