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To overcome its deficiency, healthcare professionals encourage the regular use of high-quality glutathione dietary supplements

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For instance, iron-based nanomaterials can release Fe + under acidic TME conditions, generating ROS via Fenton reactions to trigger ferroptosis (314) ;Similarly, natural product derivatives, such as artemisinin and its analogs, exploit tumor-accumulated iron to modulate ferroptotic pathways (315)

Repositioning itraconazole for amelioration of bleomycin-induced pulmonary fibrosis: Targeting HMGB1/TLR4 Axis, NLRP3 inflammasome/NF-B signaling, and autophagy