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Furthermore, some studies suggest that impaired mitochondrial bioenergetics might be the main cause for neuronal cell death induced by Complex I inhibitors rotenone and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, or its active analog 1-methyl-4-phenylpyridinium [MPP + ]) [27, 86, 343]

study types: randomized controlled trials (RCTs), cohort studies, case-control studies, and animal experiments with clearly defined model construction methods

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Laskin DL, Sunil VR, Gardner CR, Laskin JD

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