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In addition, A/R-induced increases in pMLC were attenuated by pretreatment with LA in these cells, demonstrating the role of LA in the MLC pathway of tight junction regulation

There is therefore a substantial increase in oxidative stress which erodes GSH and other antioxidant defenses

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The observation that higher plasma concentrations of 2 can be achieved after oral delivery than for PZQ, coupled with the greater ex vivo potency of compound 2 , strongly suggest that further optimization will yield an orally bioavailable schistosomicidal agent that will be transformative in the clinical setting

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As previously noted, the modified citrus pectin (PectaSol-C) in HM Complex is clinically significant because its low molecular weight allows it to cross the intestinal barrier