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These vitamins are essential cofactors in the biochemical pathways involved in serine synthesis

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It is composed of endothelial cells (ECs), pericytes, astrocytes, and a basement membrane

Supplementation with both ascorbic acid and glutathione has been shown to increase plasma glutathione levels

The availability of NADPH, and its non-phosphorylated precursor NAD (critical for metabolic reactions in glycolysis and CAC/OxPhos), is also constrained by NAD synthesis, which can be pharmacologically targeted in AML (43)