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A recent study showed that -lipoic acid and the SCFAs produced by Ruminococcaceae rejuvenated aged intestinal stem cells by preventing the age-associated endosome reduction (Du et al
In addition, in the last years it has been shown that different epigenetic modification such as DNA methylation, histone acetylation, regulation of methyltransferases and demethylases are implicated in OB and cancer [161, 162], including PCa development and heterogeneity [163,164,165,166]

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doi: 10.1038/s41598-020-80063-0 106 ZhangJ.OuC.ChenM

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