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10.1002/bit.23213

Freezing causes ice crystal formation that can damage the peptide structure and create aggregates that do not re-dissolve upon thawing

If your B12 deficiency is not severe, it might take a couple of shots over a few days or weeks before you start experiencing these positive changes in your well being

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When the body is low on water, it extracts too much liquid from the stool, which then becomes hard, dry and difficult to eliminate

When blood pressure falls, the body's autonomic nervous system may respond by increasing heart rate to maintain adequate cardiac output and tissue perfusion