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Michael Felberbaum, an FDA spokesman, told CNN in an email that the FDA received the preprint less than a day prior to the advisory committee meeting, and the information was therefore not provided in an adequate timeframe for it to be included in the agencys meeting materials, and generally the FDA only discusses data at advisory committee meetings that the agency has had the opportunity to substantively review. Numerous studies support the finding that the COVID-19 vaccines remain the best defense against the most devastating consequences of COVID-19 such as hospitalization and death, and that the updated vaccines may help provide better protection against the currently circulating variants, Felberbaum wrote

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Heparanase mediates renal dysfunction during early sepsis in mice