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The significance of mitochondrial toxicity testing in drug development

Metabolite addback and inhibitor treatment experiments were performed in the media conditions listed with supplementation of the listed metabolite or drug with equal volumes of vehicle control unless otherwise specified

Unfortunately, theory doesnt transfer into practice here

Supplementary Table S1 provides a summary of the key resources used in this process

Mutations in the ACAA2 gene are extremely rare with only a single child in the United States having been identified with a mutant form of this enzyme

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