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During synaptic activity, astrocytes rapidly clear synaptic glutamate via Na + -dependent transporters (GLT-1/GLAST), activating the Na + /K + -ATPase which establishes a Na + gradient driving GLUT1/3-mediated glucose uptake

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Specifically, the addition of cuprizone (bis-cyclohexanone oxalydihydrazone), to the diet process (66) produces a massive demyelination in different areas of the CNS and particularly in the corpus callosum (67-69)

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[DOI] [PubMed] [Google Scholar] 203.Kalayarasan S, Prabhu PN, Sriram N, Manikandan R, Arumugam M, Sudhandiran G