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A recent meta-analysis found that those who consumed alcohol achieved higher maximal concentations (Cmax) and shorter time to Cmax (Tmax) with hydromorphone compared to placebo, although this was not observed with other opioids, including morphine (266)

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Given that one out of two postmenopausal women will fracture a bone [103], the potential for using the gut as a therapeutic target to treat osteoporosis has increased research in this area

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