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however, their effects are modest 13,14 and did not support their further development for the management of obesity in the absence of diabetes
The reason for this is that their body ceases to function as it should

It incorporates key modifications, including 14E/17R mutations to stabilize an -helical segment via a salt bridge, multiple proline substitutions (25P, 28P, 29P) to reduce -sheet formation, and N-terminal C20 fatty diacid lipidation for reversible albumin binding (Kruse et al

2020 Feb 25;11(1): PMID: 34007590

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