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Twenty-five years after the publication of the first PROTAC, these are included within the Targeted Protein Degradation (TPD) field, which encompasses all innovative strategies aimed at chemically-induced protein degradation, known generically as degraders 26

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Data are expressed as mean standard deviation Abbreviations: BMI body mass index, FBS fasting blood sugar, IRI immunoreactive insulin, HBA1c hemoglobin A1c, HDL cholesterol high density lipoprotein cholesterol, LDL cholesterol low density lipoprotein cholesterol, NEFA non-esterified fatty acid, AST aspartate aminotransferase, ALT alanine aminotransferase, GGT -glutamyl transpeptidase, CAP controlled attenuation parameter, LSM liver stiffness measurement Discussion Glutathione has a long history for the treatment of chronic liver disease by intravenous injection

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Han J, Wang B, Xiao Z, Gao Y, Zhao Y, Zhang J, et al

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2.2.6 Golgi apparatus: regulatory mechanisms in ferroptosis The Golgi apparatus is a vital organelle involved in the post-translational modification, sorting, and trafficking of proteins and lipids within the cell (81)

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