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[9] The extra effort it takes to digest food without adequate levels of these two substances can leave someone feeling extra fatigued, not to mention the fact that when we dont digest our food well, we also do not absorb the nutrients from our food well, which can result in nutrient deficiencies, further exacerbating fatigue

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81773860) and R&D Program of Beijing Municipal Education Commission (No

Brain Res 1237:511 Castro R, Rivera I, Racasco P, Camilo ME, Jakobs C, Blom HJ, de Almeida IT (2004) 5, 10-methylenetetrahydrofolate reductase (MTHFR) 677C T and 1298A C mutations are associated with DNA hypomethylation

However, these compounds have been confirmed to have significant neuroprotective and preventive activity in OIPN preclinical and clinical data [186, 187]