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When Yuyang Liu, a graduate student in his lab and first author of the study, compared SLC25A39s structure against others in the SLC family of transporters in the AlphaFold protein structure database, Liu spotted a unique extra loop in the protein

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Consequently, the Trx and Grx systems maintain the balance of thiol-disulfide interactions in the reduction/oxidation conversion of protein forms, which act as target signaling pathways to regulate disulfide stress and may act as crucial triggers to suppress disulfidptosis

10.1016/j.neulet.2015.01.048 42 CataJ

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