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Spencer CM, Faulds D

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For instance, pairing a peptide that activates glutathione-associated pathways with one that stabilizes mitochondrial membranes can both reduce ROS generation and accelerate repair

Rotigotine is a dopamine agonist, which has promising potential for the treatment of PD [188], but its use is challenging due to the low bioavailability and high first-pass effects after oral administration, as well as application-site reactions after transdermal treatment [189]