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Glucagon stimulates energy expenditure in the following ways: (1)activation of BAT via direct glucagon receptor activity and indirect fibroblast growth factor 21 (FGF 21)-dependent pathways with downstream effects of increased oxygen consumption (an indirect measure of heat production)

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A 2021 New England Journal of Medicine study found that combining semaglutide with lifestyle interventions, including exercise, led to an average 14.9% weight loss over 68 weekssignificantly more than lifestyle changes alone

Semaglutide changes the affordability equation for GLP-1 therapy, and with that, wider access comes greater clinical responsibility for every physician managing metabolic disease