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However, because there is a high degree of similarity in the sequence and structure of the kinase domains of IGF-1R and InsR, most ATP-competitive inhibitors inhibited both receptors

Continuous use can blunt growth hormone response, leading to reduced sleep benefits, stalled fat loss, and lower IGF-1 levels

Pharmacol Res 62:282287

The interaction of ions within the bilayer can change the NMR spectrum