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These cumulative observations well fit with our detection of alterations in H3 and H4 marks as well as the significant decrease of RNA proteins involved in translation events

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Underlying both patterns is the progressive functional exhaustion of tumor-specific T cells, which reflects a dynamic equilibrium between immune attack and tumor evasion, a balance that is continuously challenged within an immunosuppressive tumor microenvironment (TME) sculpted by immunoediting

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Academic press: Cambridge, MA