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After it was observed that the cells gained dendrites after plating, the manufacturer of Cnt-40 media (Cellntec) was contacted, and it was disclosed that there are low levels of -MSH (0.12 M) in the basal media

Resume therapy as appropriate, based on assessments of renal function, when oral intake and volume status are normal [see Dosage and Administration (2.5), Warnings and Precautions (5.6), Adverse Reactions (6.1, 6.2), Use in Specific Populations (8.4)]

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doi: 10.1007/s11095-011-0551-1

Many patients find that side effects diminish significantly after the first week as the body adjusts