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Prolonged overdose of B6 (150-200 mg/day) over weeks can cause severe sensory-nervous-system dysfunction and ataxia.37 With normal usage serious adverse effects are not reported for pyridoxine (vitamin B6), however, diarrhoea, emesis and rosacea-like dermatitis may be observed in some cases (38)

Basmaciyan et al

Stabilized R-ALA (e.g., Na-R-ALA) R-ALA is the more bioactive form of alpha-lipoic acid, but it presents major stability challenges when isolated

[DOI] [PubMed] [Google Scholar] 38.Moslemi F, Taheri P, Azimipoor M, Ramtin S, Hashemianfar M, Momeni-Ashjerdi A, et al

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Phase II (conjugation) then binds a molecule to the metabolite from Phase I, making it water-soluble and easily excretable