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An ASD-unrelated study of neuronal dysregulation via Niemann-Pick type C1 (NPC1) deficiency revealed that imbalanced glutamine/glutamate metabolism accompanying folate metabolism disturbances in cerebellum neurons is correlated with widespread DNA methylation defects in the genome [178]

RR and SG commented on the design and revised the manuscript
The cell maintains a 10:1 ratio of cytosolic GTP:GDP so exchange for GTP is ensured

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