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Upregulation of the glutaminase II pathway contributes to glutamate production upon glutaminase 1 inhibition in pancreatic cancer

Injection allows precise dosing with minimal waste

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Similarly, intestine-specific Znt10 KO revealed moderate systemic Mn accumulation, whereas intestine and liver double Znt10 KO resulted in severe Mn overload compared to either KO alone (Mercadante et al., 2019), suggesting that both intestine and liver ZNT10 play an essential role in Mn excretion