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Use of recombinant human interleukin-2 in conjunction with bone marrow transplantation as a model for control of minimal residual disease in Malignant hematological disorders: I Treatment of murine leukemia in conjunction with allogeneic bone marrow transplantation and IL-2-activated cell-mediated immunotherapy
This combination of enzymatic degradation and decreased cellular production leads to a gradual loss of skin density and firmness, promoting premature skin aging

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Park et al., 2015)