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Chlorambucil is an effective alkylating agent used in cancer treatment, targeting DNA replication and inducing apoptosis

This second step requires NAD+ and generates NADH, shifting the hepatic redox state toward reduction and impairing mitochondrial ATP production

Patients and methods Study overview This 12-week, randomized, multicenter, active-controlled, single-blinded hypothesis, phase II parallel-group study was conducted at 7 independent and experienced clinical research centers in the United States

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