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Systemic infusion of BM-MSCs-EVs in a mouse model of aGVHD can reduce pathological damage to multiple organs targeted by aGVHD and prolong animal survival

The evidence: Extends lifespan and reduces frailty in mice

Navaneethan et al., 2015

65 An increased level of inflammatory cytokines and leukocyte activity can lead to the capillary microthrombi resulting in microvascular dysfunction

Furthermore, curcumin inhibited the Wnt and mTOR signaling pathways through the downregulation of UCA1, suggesting that curcumin exerts its anticancer effects in lung cancer by targeting the UCA1Wnt/mTOR axis (Wang W.-H

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