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Future directions: metabolic regulation and precision therapies While microglia are well-established as central to brain immunity, recent findings reveal their mechanistic roles in synaptic plasticity via C1q/C3 complement-mediated pruning and TREM2-DAP12-dependent phagocytosis, directly regulating neuronal survival and circuit homeostasis

doi: 10.1136/bmjdrc-2020-001773 131 CurtisJMGrimsrudPAWrightWSXuXFonceaREGrahamDWet al

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65 Immunosenescence and aging-related dysregulation of myeloid lineage cells Myeloid lineage cells are composed of various innate immune cells, such as neutrophils, macrophages, and monocytes