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The correct characterization of the basicity of the sites of protonation of multidentate ligands can be conducted using the micro and sub-micro constants

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Arnold SE, Arvanitakis Z, Macauley-Rambach SL, Koenig AM, Wang HY, Ahima RS, Craft S, Gandy S, Buettner C, Stoeckel LE, Holtzman DM, Nathan DM (2018) Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
Different studies have shown that vitamin C acts as a multiorgan targeting agent and can play a role in epigenetic level, regulation of kinase activity, inhibition of epithelialtomesenchymal transition (EMT), immunoregulatory effect, increasing oxygen sensation, prooxidant activity, etc

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