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In some embodiments, such combination therapy exhibits a synergistic therapeutic effect that is better than the separate effect of either therapeutic agent alone

Large body-composition outcome trials are lacking

Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

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A loss-of-function shRNA targeted screen in metastatic-derived cells identified Gstt1 , a member of the glutathione S -transferase superfamily, as uniquely required for dissemination and metastasis, but dispensable for primary tumour growth