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Specifically, ROS can modulate the activity of key enzymes in the glycolysis process through oxidation modification, such as hexokinase [171], phosphofructokinase-1 [172], and pyruvate kinase [173]

Another study showed that intra-articular injection of Botulinum Toxin A inhibited cartilage degradation in an OA model rat, and Lip-1 could further enhance this chondroprotective effect (Zeng et al., 2024)

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Nuclei were stained by using DAPI
In the human study, the elevation of blood lactate was suppressed by glutathione intake (placebo, 3.4 1.1 mM
