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Therefore, chronic stress-induced dysregulation of the HPA axis, potentially mediated by imbalances in gut microbiota, might be a crucial link between dysbiosis and the progression of AD (Figure 1)
Using human brain organoid models derived from induced pluripotent stem cells (iPSCs) with targeted knockout of the CNTNAP2 gene, which is associated with autism spectrum disorder (ASD), it was revealed that CNTNAP2-deficient brain organoids exhibit abnormalities such as accelerated cell cycle, increased cortical folding, disrupted glutamatergic/GABAergic synaptic pathways, and upregulation of AKT/mTOR signaling (106)

10.1172/JCI90229 121 RabotS.SzylitO.Nugon-BaudonL.MeslinJ

Compatibility study of topical 0.25% hypericin (HyBryteTM) application in subjects with mycosis fungoides: results of the HPNCTCL02 study

discovered that nebulized vitamin A is more effective than injectable vitamin A in reducing hyperoxia-induced lung injury and improving BPD treatment (176)
Due to their small size and hydrophobic surface, GPX4s have the ability to react with complex lipids in membranes (19)
