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These phenomena could alter plasma membrane properties and, consequently, cell shape

doi: 10.1016/j.jpeds.2014.06.044
Clinical signs encompass bone spicule-shaped pigment deposits, retinal atrophy, attenuation of retinal vessels, and a pale appearance of the optic nerve head [343]

As presented in Figs

Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation
