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Both in vitro and animal studies have demonstrated that astrocytes can synthesize KBs due to their ability to oxidize fatty acids (Yudkoff et al., 1997

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Mediumchain Fatty Acids Inhibit Mitochondrial Metabolism in Astrocytes Promoting Astrocyteneuron Lactate and Ketone Body Shuttle Systems
(2014) Circulation Research | Ufnal, M., Zadlo, A., Ostaszewski, R.: TMAO: A small molecule of great expectations