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For example, it has been demonstrated that melatonin can bind several target proteins, including enzymes, receptors, pores, and transporters [17]

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In addition we provide evidence that cellular compensatory mechanisms such as mitochondrial biogenesis and upregulation of lysosomal degradation pathways occur in PINK1 deficiency

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MEF cell culture Control, Bmal1 / and Cry1 / Cry2 / MEFs were cultured in DMEM (Sigma-Aldrich) supplemented with 15% FCS (Atlanta Biological) and 1% penicillin-streptomycin at 37 C with 5% CO 2

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