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These enzymes hydrolyze the N-glycosidic bond between the modified base and the sugar to release the base and generate an abasic site DNA phosphodiester backbone, and this site is, in a second step, cleaved by a lyase or endonuclease (58)

[DOI] [PMC free article] [PubMed] [Google Scholar] Ghersi-Egea JF, Strazielle N, Catala M, Silva-Vargas V, Doetsch F, Engelhardt B (2018) Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

The mechanism by which this enrichment occurs in either germline or somatic cells remains a mystery

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