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Transcript-level expression analysis of RNA-seq experiments with HISAT, stringTie and ballgown
While high doses administered over a short duration can induce symptoms such as lethargy, decreased food consumption, and weight loss in these animals, no significant mortality has been observed within specific dosage limits (Wang et al., 2004)

Considering that the physiological concentration of succinate is in the M range it does not seem that reverse electron transfer from Complex II to Complex I is a significant physiological source of mitochondrial ROS (Mailloux and Harper, 2011)
The catalytic pathway of horseradish peroxidase at high resolution

[DOI] [PubMed] [Google Scholar] 6.Barnes PR, Taylor DJ, Kemp GJ, and Radda GK