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[21] Levothyroxine may be dosed daily or weekly, however weekly dosing may be associated with higher TSH levels, elevated thyroid hormone levels, and transient "echocardiographic changes in some patients following 2-4 h of thyroxine intake"

Impairments range from subtle effects that can only be detected with special tests at levels between 0.001-0.029%, to problems with concentration, reflexes, motor control, and more, including a serious possibility of death at 0.50% or more.

Bottom line: Pick the timing you will actually stick to every single day

Kyoto, JP

& Louvard, D

Meta-analysis of Results of Testosterone Therapy on Sexual Function Based on International Index of Erectile Function Scores